Two-compartment model · IV bolus & oral dosing · Cmax, AUC, half-life
A two-compartment pharmacokinetics model simulating drug absorption, distribution and elimination. Compare IV bolus versus oral dosing, visualise plasma and tissue concentration curves, and calculate key PK parameters.
Drug movement between plasma (central) and tissue (peripheral) compartments follows first-order kinetics. Key parameters — Cmax, Tmax, AUC and half-life — determine dosing regimens. Oral absorption adds a lag phase modelled by ka.
Switch between IV and oral modes. Adjust dose, absorption rate and clearance. Watch concentration-time curves update live. A stats panel shows Cmax, Tmax, AUC and elimination half-life.
The therapeutic window — between the minimum effective concentration and the toxic level — is often surprisingly narrow. Digoxin, for example, has a therapeutic index of only 2, meaning double the normal dose can be lethal.