🧬 Epigenetics

CpG methylation: 30% Histone acetylation: 50% H3K4 methylation (active): 40% Chromatin compaction: 40% Environmental signal:

Overall expression—

Inheritance prob.—

Chromatin state—

Methylated CpG (silenced)

Acetylated histone (active)

H3K4me (active mark)

H3K9me (silent mark)

Epigenetic code
DNA methylation at CpG sites → gene silencing.
Histone acetylation → open chromatin → transcription.
H3K4me3 = active promoter; H3K9me3 = heterochromatin.